Andrea C LeBlanc Selected Research

Caspase 6

1/2021	Rare CASP6N73T variant associated with hippocampal volume exhibits decreased proteolytic activity, synaptic transmission defect, and neurodegeneration.
12/2019	Methylene blue inhibits Caspase-6 activity, and reverses Caspase-6-induced cognitive impairment and neuroinflammation in aged mice.
1/2019	Identification of Allosteric Inhibitors against Active Caspase-6.
1/2018	Rare human Caspase-6-R65W and Caspase-6-G66R variants identify a novel regulatory region of Caspase-6 activity.
1/2017	Caspase vinyl sulfone small molecule inhibitors prevent axonal degeneration in human neurons and reverse cognitive impairment in Caspase-6-overexpressing mice.
12/2016	Increased Caspase-6 activity in the human anterior olfactory nuclei of the olfactory bulb is associated with cognitive impairment.
9/2015	Methylene Blue Inhibits Caspases by Oxidation of the Catalytic Cysteine.
7/2013	Caspase-6 activity predicts lower episodic memory ability in aged individuals.
6/2013	Caspase-6 as a novel early target in the treatment of Alzheimer's disease.
8/2004	Active caspase-6 and caspase-6-cleaved tau in neuropil threads, neuritic plaques, and neurofibrillary tangles of Alzheimer's disease.

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Andrea C LeBlanc Research Topics

Disease

10	Alzheimer Disease (Alzheimer's Disease) 01/2021 - 08/2004
7	Cognitive Dysfunction 01/2021 - 07/2013
2	Carcinoma (Carcinomatosis) 01/2017 - 09/2015
1	Atrophy 01/2021
1	Neuroinflammatory Diseases 12/2019
1	Huntington Disease (Huntington's Disease) 01/2017
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2017
1	Dementia (Dementias) 12/2016
1	Neoplasms (Cancer) 09/2015
1	Scrapie 07/2009
1	Prion Diseases (Transmissible Spongiform Encephalopathies) 05/2007
1	Amyloid Plaque 08/2004

Drug/Important Bio-Agent (IBA)

10	Caspase 6IBA 01/2021 - 08/2004
3	CaspasesIBA 12/2019 - 09/2015
2	Methylene Blue (Methylthioninium Chloride)FDA Link 12/2019 - 09/2015
2	Peptide Hydrolases (Proteases)FDA Link 01/2017 - 07/2013
2	AntibodiesIBA 12/2016 - 08/2004
1	Proteins (Proteins, Gene)FDA Link 01/2021
1	Glial Fibrillary Acidic ProteinIBA 12/2019
1	phenothiazineIBA 12/2019
1	CalciumIBA 12/2019
1	Cysteine Proteases (Cysteine Protease)IBA 01/2018
1	Caspase InhibitorsIBA 01/2017
1	Aspartic Acid (Aspartate)FDA Link 01/2017
1	divinyl sulfoneIBA 01/2017
1	Amyloid (Amyloid Fibrils)IBA 12/2016
1	Immune Sera (Antisera)IBA 12/2016
1	tau Proteins (tau Protein)IBA 09/2015
1	Pharmaceutical PreparationsIBA 09/2015
1	Azure BIBA 09/2015
1	Cysteine (L-Cysteine)FDA Link 09/2015
1	Azure AIBA 09/2015
1	Amyloid beta-PeptidesIBA 07/2013
1	Alkaline PhosphataseIBA 07/2009
1	Endopeptidase K (Proteinase K)IBA 07/2009
1	Prion ProteinsIBA 05/2007
1	Caspase 3 (Caspase-3)IBA 08/2004